ultrasound-promoted synthesis of aryl amides from isocyanides and carboxylic acids under ambient conditions
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abstract
the synthesis of aryl amides via the reactions of carboxylic acids and isocyanides in methanol was carried out in 78-95% yields under ultrasound irradiation. the method has wide applicability, and the protocol is mild, fast and efficient compared to the existing methods based on silent conditions.
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Ultrasound-Promoted Synthesis of Aryl Amides from Isocyanides and Carboxylic Acids under Ambient Conditions
The synthesis of aryl amides via the reactions of carboxylic acids and isocyanides in methanol was carried out in 78-95% yields under ultrasound irradiation. The method has wide applicability, and the protocol is mild, fast and efficient compared to the existing methods based on silent conditions.
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some amide derivatives have been synthesized by the reaction of corresponding nitriles with potassium tert-butoxide as a nucleophilic oxygen source under ultrasonic irradiation. this new methodology provides good to excellent yields in short reaction times (15-90 min) at room temperature.
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full textThe three-component reaction of 2-(2-oxopropyl)isoindoline-1,3-dione with alkyl isocyanides and aromatic carboxylic acids under catalyst-free conditions in water
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Journal title:
organic chemistry researchPublisher: iranian chemical society
ISSN
volume 1
issue 1 2015
Keywords
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